liens 555 55 55 55
18
JUIN
2019
mRNA cancer vaccines
mRNA cancer vaccines are a promising type of immunotherapy designed to stimulate the body’s immune system to recognize and attack cancer cells. They work by delivering synthetic messenger RNA (mRNA) that encodes cancer-specific antigens, prompting the immune system to generate a targeted response.
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How It Works:
mRNA Delivery: The vaccine contains lab-made mRNA encoding tumor-specific antigens.
Uptake by Cells: After injection, the mRNA is taken up by immune cells (especially dendritic cells).
Protein Translation: These cells translate the mRNA into cancer-associated proteins (antigens).
Immune Activation: The immune system identifies these antigens as foreign and mounts a T-cell response to kill cancer cells displaying them.
🎯 Target Types:
Personalized (Neoantigen-based): Custom-made for each patient based on the unique mutations in their tumor.
Shared Antigen-based: Targets antigens common across many patients/tumors (e.g., HER2, KRAS).
⚙️ Advantages:
Highly customizable (especially for personalized vaccines)
Rapid and scalable production
No risk of integrating into the host genome
Can be combined with other therapies (e.g., checkpoint inhibitors)